Genetics of Individuality

Informazioni relative al progetto

IndiGene

ID dell’accordo di sovvenzione: 810172

DOI

10.3030/810172

Progetto chiuso

Data della firma CE 18 Gennaio 2019

Data di avvio 1 Febbraio 2019

Data di completamento 31 Luglio 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 6 272 613,00

Contributo UE

€ 6 272 613,00

Coordinato da

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Data Management Plan for the Open Research Data Pilot

Pubblicazioni

Peer reviewed articles (17)

Characterizing medaka visual features using a high-throughput optomotor response assay

Autori: Risa Suzuki, Jia Zheng Woo, Thomas Thumberger, Gero Hofmann, Joachim Wittbrodt, Tinatini Tavhelidse-Suck
Pubblicato in: PLOS ONE, Numero 19, 2024, Pagina/e e0302092, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0302092

Genomic variations and epigenomic landscape of the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

Autori: Adrien Leger, Ian Brettell, Jack Monahan, Carl Barton, Nadeshda Wolf, Natalja Kusminski, Cathrin Herder, Narendar Aadepu, Clara Becker, Jakob Gierten, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Tinatini Tavhelidse, Thomas Thumberger, Erika Tsingos, Philip Watson, Bettina Welz, Kiyoshi Naruse, Felix Loosli, Joachim Wittbrodt, Ewan Birney & Tomas Fitzg
Pubblicato in: Genome Biology, Numero 23, Article number: 58, 2022, ISSN 1474-760X
Editore: Springer Nature
DOI: 10.1186/s13059-022-02602-4

Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

Autori: Lucie Zilova, Venera Weinhardt, Tinatini Tavhelidse, Christina Schlagheck, Thomas Thumberger, Joachim Wittbrodt
Pubblicato in: eLife, Numero 10, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.66998

Boosting targeted genome editing using the hei-tag

Autori: Thomas ThumbergerTinatini Tavhelidse-SuckJose Arturo Gutierrez-TrianaAlex CorneanRebekka MedertBettina WelzMarc FreichelJoachim Wittbrodt
Pubblicato in: eLife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.70558

FlexLMM: a Nextflow linear mixed model framework for GWAS

Autori: Saul Pierotti, Tomas Fitzgerald, Ewan Birney
Pubblicato in: Bioinformatics, Numero 41, 2025, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf021

The Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel

Autori: Tomas Fitzgerald, Ian Brettell, Adrien Leger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Lischik, Katharina Lust, Natalia Sokolova, Risa Suzuki, Erika Tsingos, Tinatini Tavhelidse, Thomas Thumberger, Philip Watson, Bettina Welz, Nadia Khouja, Kiyoshi Naruse, Ewan Birney, Joachim Wittb
Pubblicato in: Genome Biology, Numero 23, Article number: 59, 2022, ISSN 1474-760X
Editore: Springer Nature
DOI: 10.1186/s13059-022-02623-z

Genotype imputation in F2 crosses of inbred lines

Autori: Saul Pierotti, Bettina Welz, Mireia Osuna-López, Tomas Fitzgerald, Joachim Wittbrodt, Ewan Birney
Pubblicato in: Bioinformatics Advances, Numero 4, 2024, ISSN 2635-0041
Editore: Oxford University Press
DOI: 10.1093/bioadv/vbae107

Natural genetic variation quantitatively regulates heart rate and dimension

Autori: Jakob Gierten, Bettina Welz, Tomas Fitzgerald, Thomas Thumberger, Rashi Agarwal, Oliver Hummel, Adrien Leger, Philipp Weber, Kiyoshi Naruse, David Hassel, Norbert Hübner, Ewan Birney, Joachim Wittbro
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-59425-7

Measurement and classification of bold–shy behaviours in medaka fish

Autori: Saul Pierotti, Ian Brettell, Tomas Fitzgerald, Cathrin Herder, Narendar Aadepu, Christian Pylatiuk, Joachim Wittbrodt, Ewan Birney, Felix Loosli
Pubblicato in: Bioinformatics, Numero 41, 2025, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf342

Establishing an auxin-inducible GFP nanobody-based acute protein knockdown system to mimic hypomorphic mutations during early medaka embryogenesis

Autori: Kaisa Pakari, Sevinç Jakab, Johanna Rasch, Encarnación Sánchez Salvador, Beate Wittbrodt, Christian Thiel, Joachim Wittbrodt, Thomas Thumberger
Pubblicato in: Biology Open, Numero 14, 2025, ISSN 2046-6390
Editore: The Company of Biologists
DOI: 10.1242/bio.062081

FEHAT: efficient, large scale and automated heartbeat detection in Medaka fish embryos

Autori: Marcio Soares Ferreira, Sebastian Stricker, Tomas Fitzgerald, Jack Monahan, Fanny Defranoux, Philip Watson, Bettina Welz, Omar Hammouda, Joachim Wittbrodt, Ewan Birney
Pubblicato in: Bioinformatics, Numero 40, 2024, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btae664

Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions

Autori: Jakob Gierten, Christian Pylatiuk, Omar T. Hammouda, Christian Schock, Johannes Stegmaier, Joachim Wittbrodt, Jochen Gehrig, Felix Loosli
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-58563-w

De novo PAM generation to reach initially inaccessible target sites for base editing

Autori: Kaisa Pakari, Joachim Wittbrodt, Joachim Wittbrodt
Pubblicato in: Development, 2023, ISSN 0950-1991
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dev.201115

Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells

Autori: Jian-Hua Chen, Bieke Vanslembrouck, Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
Pubblicato in: Viruses, Numero 14, 2025, Pagina/e 2651, ISSN 1999-4915
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14122651

CRISPR-based knockout and base editing confirm the role of MYRF in heart development and congenital heart disease

Autori: Lino Doering, Alex Cornean, Thomas Thumberger, Joergen Benjaminsen, Beate Wittbrodt, Tanja Kellner, Omar T. Hammouda, Matthias Gorenflo, Joachim Wittbrodt and Jakob Gierten
Pubblicato in: | Disease Models & Mechanisms, 2023, ISSN 1754-8403
Editore: The Company of Biologists Ltd.
DOI: 10.1242/dmm.049811

Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction

Autori: Alex Cornean, Jakob Gierten, Bettina Welz, Juan Luis Mateo, Thomas Thumberger, Joachim Wittbrodt
Pubblicato in: eLife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.72124

Visualisation of gene expression within the context of tissues using an X-ray computed tomography-based multimodal approach

Autori: Kristaps Kairišs, Natalia Sokolova, Lucie Zilova, Christina Schlagheck, Robert Reinhardt, Tilo Baumbach, Tomáš Faragó, Thomas van de Kamp, Joachim Wittbrodt, Venera Weinhardt
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-58766-5