Descrizione del progetto
Piccoli cristalli di qualità elevata nello sviluppo farmacologico
I principi attivi farmaceutici, gli elementi che forniscono ai farmaci la loro bioattività, sono generalmente prodotti come cristalli. I cristalli grandi possono impedire la dissoluzione dei composti in solventi acquosi, il che rappresenta una sfida allo sviluppo e alla distribuzione dei farmaci. I mesocristalli sono materiali composti da singoli cristalli di piccole dimensioni aggregati, ma separati a livello spaziale, un formato che consente di migliorare la penetrazione dell’acqua e la dissoluzione. Il progetto OMECRY, finanziato dall’UE, applicherà metodi sperimentali avanzati per caratterizzare la formazione dei mesocristalli, i tassi di dissoluzione e la solubilità con l’obiettivo di controllare in definitiva la formazione dei mesocristalli e supportare lo sviluppo di principi attivi innovativi per i farmaci.
Obiettivo
The OMECRY research action aims to enhance the dissolution of pharmaceutical solids in the form of mesocrystals, i.e. to promote the drug development. I will also investigate the formation mechanisms of the organic mesocrystals, and influence of the different additives on these processes. The low dissolution rate and poor aqueous solubility of emerging new drug candidates limit the formulation approaches, clinical application, and marketability in pharmaceutical industry. The preparation of active pharmaceutical ingredients (APIs) in the form of mesocrystals can enhance the dissolution rate suitable for drug delivery. The voids between highly oriented nanocrystals and high surface area of hierarchical structure in the non-classical pathway of mesocrystals formation play a role in the process. Different additives can be used to control the self-assembly of particles so that avoiding mesocrystals fusion into single crystals. A suitable additive can be screened through density functional theory calculations. The microstructure of mesocrystals and its transformation and particle growth can be investigated through time-dependent experiments using SEM, TEM and laser diffraction particle size analyser. Computed Tomography will be used for the first time to obtain the density mapping of mesocrystals surface in phase contrast mode. The dissolution rates and solubility of the mesocrystals are characterized and compared to its single crystals. The feasibility of drug dissolution will be investigated through in vitro studies. Although many inorganic mesocrystals has prepared for photocatalysis, energy storage applications, formation APIs in mesocrystals is a new strategy which provides insights that are needed for further understanding of mesocrystals formations thereby improve its applications especially for drug development.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural scienceschemical sciencescatalysisphotocatalysis
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- engineering and technologynanotechnologynano-materialsnanocrystals
- natural sciencesphysical sciencesopticslaser physics
Programma(i)
Argomento(i)
Meccanismo di finanziamento
MSCA-IF-EF-ST - Standard EFCoordinatore
02150 Espoo
Finlandia