Opis projektu
Nowy mikroskop do wychwytywania komórek
REVEAL to finansowany ze środków UE multidyscyplinarny projekt, którego celem jest opracowanie rewolucyjnej techniki mikroskopowej umożliwiającej dwu- i trójwymiarowe obrazowanie żywych komórek. Dzięki uczeniu maszynowemu mikroskop będzie w stanie wychwytywać i interpretować zdarzenia komórkowe, które mogą prowadzić do przemiany komórek w komórki złośliwe. Umożliwi on użytkownikom wykrywanie i pobieranie różnych typów komórek wątroby, które następnie będą analizowane na poziomie molekularnym i biochemicznym. Projekt pozwoli na powiązanie obserwowanych pod mikroskopem fenotypów komórkowych z profilami ekspresji genów, oferując istotne informacje na temat komórkowego podłoża raka wątroby.
Cel
The REVEAL project aims at installing a novel microscope at the interface of instrumentation, machine learning and Biology. This new microscopy technique will rely heavily on neural networks to be able to perceive, interpret, conjecture, infer, anticipate and act. The present project intends to lay down the foundations of this ‘neuronal microscopy’ in the realms of 2D and 3D cell live imaging.
To achieve this goal, we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this new microscopy framework. In particular, we will develop a ‘cell picking neuronal microscope’ that will allow us to detect and collect different subtype of liver cells that are due to become tumoral and analyse them ahead of tumour manifestation. This analysis will help us to characterize the cellular heterogeneity known to exist at the origin of liver cancer. It will provide a direct mapping between cellular phenotypes observed under microscope and gene expression present in the early stages of liver cancer. Overall, we are thus defining a novel methodology, giving a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.
REVEAL is a multidisciplinary project engaging 7 EU partners (2 being SMEs) from 4 countries covering the RTO, academic and industrial worlds, including medical doctors. An implementation plan is presented in the form of 6 work packages, 4 of them being technical. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the project impact. Solutions to overcome the technological barriers, as well as appropriate deliverables, tasks, milestones and risks are presented, in order to complete the project objectives in due time . The REVEAL project outcomes are fully in line with the H2020 ICT-36-2020 call, subtopic iv, as it will develop novel methods and devices as research tools to understand the cellular origin of diseases.
Dziedzina nauki
Słowa kluczowe
Program(-y)
Zaproszenie do składania wniosków
Zobacz inne projekty w ramach tego zaproszeniaSzczegółowe działanie
H2020-ICT-2020-2
System finansowania
RIA - Research and Innovation actionKoordynator
75015 PARIS 15
Francja