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Training AlliancE for Novel Microbiome-Modulating TherapieS

Descrizione del progetto

Piattaforma di formazione per la scoperta di farmaci con particolare attenzione alle modifiche terapeutiche del microbiota

Il progetto TALENTS, finanziato dal programma di azioni Marie Skłodowska-Curie, si propone di costruire un’alleanza internazionale per la formazione interdisciplinare di 15 dottorandi come ricercatori di nuova generazione in ambito farmaceutico. I singoli progetti sono strutturati in modo tale da concentrarsi sullo studio del microbioma e delle modifiche terapeutiche del microbiota, delle alternative agli antibiotici tradizionali per ridurre il rischio dello sviluppo di resistenze e dei mezzi di somministrazione di nuovi agenti terapeutici. L’obiettivo generale è quello di elaborare nuovi modelli di malattia e metodi analitici. Scoprendo correlazioni e legami fra il microbiota e l’origine delle malattie, TALENTS permetterà di fare passi avanti nella scoperta di terapie innovative che modulano il microbioma.

Obiettivo

TALENTS aims to build up an international programme for interdisciplinary and transsectorial training of 15 doctoral candidates (DCs) as needed for the next generation of drug researchers. Research projects are structured in 3 clusters (PCs): PC1 will investigate the microbiome by transcriptomic and metagenomic analysis of diseases to identify and isolate microorganisms/metabolites for therapeutically modifying the microbiota. PC2 will focus on pathoblockers targeting virulence factors as alternative to traditional antibiotics with lower risk of resistance development. PC3 will address the delivery needs across biological barriers, to achieve efficient and targeted transport to the site of action. Throughout the PC structure of 15 individual, but interconnected research projects, we aim to develop and exchange disease models, analytical methods and microbiome-related results. By generating knowledge on correlations and causalities between microbiota and disease TALENTS will advance the development of novel microbiome-modulating therapies
TALENTS is builds on an earlier joint venture of Saarland University, University Clinics Saarland and Helmholtz Institute for Pharmaceutical Research Saarland to foster transdisciplinary doctoral training between different faculties and institutions. In addition, TALENTS is intersectorial by implementing a unique supervision structure for each DC with an external expert advisor and translation-oriented training for individual career development, also including secondments in a complementary industrial or clinical sector. Working on challenging research projects, the candidates will acquire specific knowledge and skills at the interface of clinical medicine, microbiology and pharmaceutical science, pivotal for state-of-the-art infection research and microbiome interventions.
By collaborations of experts from natural sciences, medicine, and bioinformatics, TALENTS provides high-level multidisciplinary and intersectorial training.

Coordinatore

UNIVERSITAT DES SAARLANDES
Contribution nette de l'UE
€ 1 512 000,00
Indirizzo
CAMPUS
66123 Saarbrucken
Germania

Mostra sulla mappa

Regione
Saarland Saarland Regionalverband Saarbrücken
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partner (16)