Cel This application is to partially fund a junior research position at the Oulu Biocenter (BCO) and the Department of Biochemistry, University of Oulu, concerning structural determination of human adenosine receptor subtype selectivity and allosteric modulation. As a basis of this project, we recently determined the crystal structure of the human adenosine A2A receptor. By the research described in the research plan, we will accomplish one or more of following goals (2010-2014): To solve human adenosine A1, A2A, A2B and A3 structure complexes with subtype-selective ligands and co-factors. To study allosteric modulation of adenosine receptors. To study the functional/structural role of lipids those were co-crystallized in the initial A2A structure. To determine the structure of carboxy terminal domain(s) of human A2A receptor and further characterize its functional properties and interaction partners. To biophysically characterize the dynamic and conformational changes upon ligand/co-factor binding in the purified adenosine receptor those are important to the activation mechanism. The main goal is to establish an independent research team and equipments at the BCO. The team would be specialized on structural and functional studies of GPCRs. The BCO and the protein science facilities available at Oulu University provides excellent environment for the research proposed, with access to instruments and facilities needed for the proposed research. The major collaborators in this project include R.C.Stevens (the Scripps Research Institute, USA) and A. Ijzeman (University of Leiden, Netherlands). We will seek more collaboration nationally and internationally on GPCRs and biophysical characterization of the targets. With this application, partial salary of the PI is applied. The BCO is committed support a start up package for setting up a laboratory, an annual grant for materials and consumables and salary for two other project members for this proposal. Dziedzina nauki inżynieria i technologiainżynieria materiałowakryształynauki przyrodniczenauki biologicznebiochemiabiocząsteczkibiałkanauki przyrodniczenauki biologicznebiochemiabiocząsteczkilipidy Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2009-RG - Marie Curie Action: "Reintegration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2009-RG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IRG - International Re-integration Grants (IRG) Koordynator OULUN YLIOPISTO Adres Pentti kaiteran katu 1 90014 Oulu Finlandia Zobacz na mapie Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Leila Risteli (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Wkład UE € 100 000,00
