Cel The emergence of jawed vertebrates (gnathostomes) is a pivotal event in vertebrate evolution, based on the evolution of jaws with teeth. This was thought to represent a key vertebrate innovation, allowing jawed vertebrates to outcompete their jawless rivals. Recent discoveries however, shed a different light on the evolution of teeth and jaws. i) tooth-like structures were found on gill arches in a primitive jawless vertebrate, indicating that teeth evolved prior to jaws. ii) the first jawed vertebrates appear to be toothless. These data demonstrate that tooth and jaw evolution were not coordinated, contradicting previous scenarios. Among living gnathostomes, the two major groups are chondrichthyans (shark, rays) and osteichthyans (bony jawed vertebrates). Crucially, we lack insight into the development of teeth and jaws in early osteichthyans. Our current knowledge is based only on two members of this clade, representing two important laboratory models: the Zebrafish, an actinopterygian, and mouse, a sarcopterygian tetrapod. These are the two fundamental lineages that comprise Osteichthyes, diverging 400+ million years ago. However, zebrafish and Mouse are derived osteichthyans, and not representative the early osteichthyans.The question of how vertebrate jaws and teeth evolved is best answered in a multidisciplinary approach, providing necessary phylogenetic and developmental context to interpret data from basal osteichthyans. Only then can we find new hypotheses of how complex modules evolved. My proposed project offers a rare opportunity to investigate evolution and assembly of a jjaws and teeth. A pivotal part of this project will employ cutting edge 3D imaging techniques to analyze fossil data, essential because organisms in which these modules first evolved are long extinct. Only data fossil jawed vertebrates can answer the specific question of how jaws and teeth evolved, fundamental to understanding jawed vertebrate origins, and thus, our own evolution. Dziedzina nauki natural sciencesbiological sciencesevolutionary biology Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Zaproszenie do składania wniosków FP7-PEOPLE-2013-IEF Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IEF - Intra-European Fellowships (IEF) Koordynator UNIVERSITY OF BRISTOL Wkład UE € 299 558,40 Adres BEACON HOUSE QUEENS ROAD BS8 1QU Bristol Zjednoczone Królestwo Zobacz na mapie Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Maria Davies (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych