Rezultaty
Identification of RSV antigen for alternative vaccination routes
Immunological properties of the modified GBS antigenBio-distribution of lipid nanoparticles
Identification of self-amplifying Rabies RNA construct
Identification of self-amplifying RSV RNA construct
Optimised adjuvant system for GBS antigen presentationOptimised adjuvant system for a Rabies vaccine
Optimised adjuvant system for an RSV vaccine
Model to investigate intracellular ROS, antigen presentation and specific T cell responsesEvaluating polymeric particles, cationic emulsions and lipoplex formulations
Bio-distribution of adjuvants and associated antigens–mucosal routes
Metabolic factors that contribute to the impaired adaptive immunity in older adults
Key physico-chemical attributes of alum, emulsion, liposome and nanoparticle systems shown to be effective as adjuvants
Bio-distribution of adjuvants and their associated antigen - 1
Comparing the immune response efficacy of antigen and adjuvant combinations - mucosal routes
Optimised adjuvant attributes for self-amplifying RNA vaccines
Bio-distribution of selected polymeric particles, cationic emulsions and lipoplexes
Evaluation of the immune response efficacy
Comparison of cellular uptake in monocyte-derived macrophages and dendritic cells
Structural flexibility of the MenB Antigen
Structural flexibility of the GBS Antigen
Impact of adjuvant designIdentification of T-cell epitopes
Modulation of T-cell epitope affinity
Key biophysical and physico-chemical attributes of current lipid nanoparticles
Bio-distribution of adjuvants and their associated antigen - 2
Adjuvant properties identified
Correlation of adjuvant properties (identified in WP2) with efficacy of immunisation
Interactions of GBS and Rabies antigen and adjuvants
Interactions of GBS and RSV antigen and adjuvants
4 ESRs with the skills and methods to ensure they can enthusiastically convey their science and reach all audiences
Deliver Outreach events at the British Science Festival and using on-line media
4 ESRs trained to PhD level
ESRs who will make a quantifiable difference with their research through engagement with a full range of stakeholders and external partners
Agreement and implementation of a data management plan.
Publikacje
Autorzy:
Gustavo Lou, Giulia Anderluzzi, Signe Tandrup Schmidt, Stuart Woods, Simona Gallorini, Michela Brazzoli, Fabiola Giusti, Ilaria Ferlenghi, Russell Johnson, Craig W. Roberts, Derek T. O'Hagan, Barbara C. Baudner, Yvonne Perrie
Opublikowane w:
Journal of Controlled Release, Numer Online ahead of print., 2020, Strona(/y) Online ahead of print., ISSN 0168-3659
Wydawca:
Elsevier BV
DOI:
10.1016/j.jconrel.2020.06.027
Autorzy:
Giulia Anderluzzi, Gustavo Lou, Yang Su, Yvonne Perrie
Opublikowane w:
Pharmaceutical Nanotechnology, Numer 7/6, 2019, Strona(/y) 444-459, ISSN 2211-7385
Wydawca:
Bentham Science
DOI:
10.2174/2211738507666190925112942
Autorzy:
Giulia Anderluzzi, Yvonne Perrie
Opublikowane w:
Drug Delivery Letters, Numer 09, 2019, ISSN 2210-3031
Wydawca:
Bentham Science
DOI:
10.2174/2210303109666190807104437
Autorzy:
Gustavo Lou, Giulia Anderluzzi, Stuart Woods, Craig W. Roberts, Yvonne Perrie
Opublikowane w:
European Journal of Pharmaceutics and Biopharmaceutics, Numer 143, 2019, Strona(/y) 51-60, ISSN 0939-6411
Wydawca:
Elsevier BV
DOI:
10.1016/j.ejpb.2019.08.013
Autorzy:
Giulia Anderluzzi, Gustavo Lou, Simona Gallorini, Michela Brazzoli, Russell Johnson, Derek T. O’Hagan, Barbara C. Baudner, Yvonne Perrie
Opublikowane w:
Vaccines, Numer 8/2, 2020, Strona(/y) 212, ISSN 2076-393X
Wydawca:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/vaccines8020212
Autorzy:
Cameron Webb, Neil Forbes, Carla B. Roces, Giulia Anderluzzi, Gustavo Lou, Suraj Abraham, Logan Ingalls, Keara Marshall, Timothy J. Leaver, Julie A. Watts, Jonathan W. Aylott, Yvonne Perrie
Opublikowane w:
International Journal of Pharmaceutics, Numer 582, 2020, Strona(/y) 119266, ISSN 0378-5173
Wydawca:
Elsevier BV
DOI:
10.1016/j.ijpharm.2020.119266
Autorzy:
Roshan Goswami, Despo Chatzikleanthous, Gustavo Lou, Fabiola Giusti, Alessandra Bonci, Marianna Taccone, Michela Brazzoli, Simona Gallorini, Ilaria Ferlenghi, Francesco Berti, Derek T. O’Hagan, Carlo Pergola, Barbara C. Baudner, Roberto Adamo
Opublikowane w:
ACS Infectious Diseases, Numer 5/9, 2019, Strona(/y) 1546-1558, ISSN 2373-8227
Wydawca:
ACS
DOI:
10.1021/acsinfecdis.9b00084
Autorzy:
Despo Chatzikleanthous, Robert Cunliffe, Filippo Carboni, Maria Rosaria Romano, Derek T. O'Hagan, Craig W. Roberts, Yvonne Perrie, Roberto Adamo
Opublikowane w:
MethodsX, Numer 7, 2020, Strona(/y) 100942, ISSN 2215-0161
Wydawca:
ELSEVIER
DOI:
10.1016/j.mex.2020.100942
Autorzy:
Despo Chatzikleanthous, Signe Tandrup Schmidt, Giada Buffi, Ida Paciello, Robert Cunliffe, Filippo Carboni, Maria Rosaria Romano, Derek T. O'Hagan, Ugo D'Oro, Stuart Woods, Craig W. Roberts, Yvonne Perrie, Roberto Adamo
Opublikowane w:
Journal of Controlled Release, Numer 323, 2020, Strona(/y) 125-137, ISSN 0168-3659
Wydawca:
Elsevier BV
DOI:
10.1016/j.jconrel.2020.04.001
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