Rezultaty Documents, reports (26) Identification of Rabies antigen for alternative vaccination routes Identification of RSV antigen for alternative vaccination routes Immunological properties of the modified GBS antigen Bio-distribution of lipid nanoparticles Identification of self-amplifying Rabies RNA construct Identification of self-amplifying RSV RNA construct Optimised adjuvant system for GBS antigen presentation Optimised adjuvant system for a Rabies vaccine Optimised adjuvant system for an RSV vaccine Model to investigate intracellular ROS, antigen presentation and specific T cell responses Evaluating polymeric particles, cationic emulsions and lipoplex formulations Bio-distribution of adjuvants and associated antigens–mucosal routes Metabolic factors that contribute to the impaired adaptive immunity in older adults Key physico-chemical attributes of alum, emulsion, liposome and nanoparticle systems shown to be effective as adjuvants Bio-distribution of adjuvants and their associated antigen - 1 Comparing the immune response efficacy of antigen and adjuvant combinations - mucosal routes Optimised adjuvant attributes for self-amplifying RNA vaccines Bio-distribution of selected polymeric particles, cationic emulsions and lipoplexes Evaluation of the immune response efficacy Comparison of cellular uptake in monocyte-derived macrophages and dendritic cells Structural flexibility of the MenB Antigen Structural flexibility of the GBS Antigen Impact of adjuvant design Identification of T-cell epitopes Modulation of T-cell epitope affinity Key biophysical and physico-chemical attributes of current lipid nanoparticles Bio-distribution of adjuvants and their associated antigen - 2 Adjuvant properties identified Correlation of adjuvant properties (identified in WP2) with efficacy of immunisation Interactions of GBS and Rabies antigen and adjuvants Interactions of GBS and RSV antigen and adjuvants Other (5) 4 ESRs with the skills to influence, cause an effect, and lead on policy development and economic prosperity in their research field 4 ESRs with the skills and methods to ensure they can enthusiastically convey their science and reach all audiences Deliver Outreach events at the British Science Festival and using on-line media 4 ESRs trained to PhD level ESRs who will make a quantifiable difference with their research through engagement with a full range of stakeholders and external partners Open Research Data Pilot (1) Data management plan Agreement and implementation of a data management plan. Publikacje Peer reviewed articles (9) Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection Autorzy: Gustavo Lou, Giulia Anderluzzi, Signe Tandrup Schmidt, Stuart Woods, Simona Gallorini, Michela Brazzoli, Fabiola Giusti, Ilaria Ferlenghi, Russell Johnson, Craig W. Roberts, Derek T. O'Hagan, Barbara C. Baudner, Yvonne Perrie Opublikowane w: Journal of Controlled Release, Numer Online ahead of print., 2020, Strona(/y) Online ahead of print., ISSN 0168-3659 Wydawca: Elsevier BV DOI: 10.1016/j.jconrel.2020.06.027 Scalable Manufacturing Processes for Solid Lipid Nanoparticles Autorzy: Giulia Anderluzzi, Gustavo Lou, Yang Su, Yvonne Perrie Opublikowane w: Pharmaceutical Nanotechnology, Numer 7/6, 2019, Strona(/y) 444-459, ISSN 2211-7385 Wydawca: Bentham Science DOI: 10.2174/2211738507666190925112942 Microfluidic Manufacture of Solid Lipid Nanoparticles: A Case Study on Tristearin-Based Systems. Autorzy: Giulia Anderluzzi, Yvonne Perrie Opublikowane w: Drug Delivery Letters, Numer 09, 2019, ISSN 2210-3031 Wydawca: Bentham Science DOI: 10.2174/2210303109666190807104437 A novel microfluidic-based approach to formulate size-tuneable large unilamellar cationic liposomes: Formulation, cellular uptake and biodistribution investigations Autorzy: Gustavo Lou, Giulia Anderluzzi, Stuart Woods, Craig W. Roberts, Yvonne Perrie Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 143, 2019, Strona(/y) 51-60, ISSN 0939-6411 Wydawca: Elsevier BV DOI: 10.1016/j.ejpb.2019.08.013 Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines Autorzy: Giulia Anderluzzi, Gustavo Lou, Simona Gallorini, Michela Brazzoli, Russell Johnson, Derek T. O’Hagan, Barbara C. Baudner, Yvonne Perrie Opublikowane w: Vaccines, Numer 8/2, 2020, Strona(/y) 212, ISSN 2076-393X Wydawca: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/vaccines8020212 Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes Autorzy: Cameron Webb, Neil Forbes, Carla B. Roces, Giulia Anderluzzi, Gustavo Lou, Suraj Abraham, Logan Ingalls, Keara Marshall, Timothy J. Leaver, Julie A. Watts, Jonathan W. Aylott, Yvonne Perrie Opublikowane w: International Journal of Pharmaceutics, Numer 582, 2020, Strona(/y) 119266, ISSN 0378-5173 Wydawca: Elsevier BV DOI: 10.1016/j.ijpharm.2020.119266 Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines Autorzy: Roshan Goswami, Despo Chatzikleanthous, Gustavo Lou, Fabiola Giusti, Alessandra Bonci, Marianna Taccone, Michela Brazzoli, Simona Gallorini, Ilaria Ferlenghi, Francesco Berti, Derek T. O’Hagan, Carlo Pergola, Barbara C. Baudner, Roberto Adamo Opublikowane w: ACS Infectious Diseases, Numer 5/9, 2019, Strona(/y) 1546-1558, ISSN 2373-8227 Wydawca: ACS DOI: 10.1021/acsinfecdis.9b00084 Synthesis of protein conjugates adsorbed on cationic liposomes surface Autorzy: Despo Chatzikleanthous, Robert Cunliffe, Filippo Carboni, Maria Rosaria Romano, Derek T. O'Hagan, Craig W. Roberts, Yvonne Perrie, Roberto Adamo Opublikowane w: MethodsX, Numer 7, 2020, Strona(/y) 100942, ISSN 2215-0161 Wydawca: ELSEVIER DOI: 10.1016/j.mex.2020.100942 Design of a novel vaccine nanotechnology-based delivery system comprising CpGODN-protein conjugate anchored to liposomes Autorzy: Despo Chatzikleanthous, Signe Tandrup Schmidt, Giada Buffi, Ida Paciello, Robert Cunliffe, Filippo Carboni, Maria Rosaria Romano, Derek T. O'Hagan, Ugo D'Oro, Stuart Woods, Craig W. Roberts, Yvonne Perrie, Roberto Adamo Opublikowane w: Journal of Controlled Release, Numer 323, 2020, Strona(/y) 125-137, ISSN 0168-3659 Wydawca: Elsevier BV DOI: 10.1016/j.jconrel.2020.04.001 Wyszukiwanie danych OpenAIRE... Podczas wyszukiwania danych OpenAIRE wystąpił błąd Brak wyników
