Opis projektu
Rewolucja w dziedzinie testów diagnostycznych
Testy diagnostyczne mają kluczowe znaczenie dla wyciągania skutecznych wniosków podczas analizowania i odkrywania nowych patogenów opornych i chorób zakaźnych. Niestety, obecne techniki diagnostyczne wykorzystują metody hodowli lub PCR, co prowadzi do poważnych niedogodności, często utrudniając scharakteryzowanie nowych patogenów w określonym czasie 3 godzin. Celem finansowanego ze środków UE projektu MARA jest rozwiązanie tego problemu poprzez opracowanie i wprowadzenie rewolucyjnego rozwiązania opartego na trzech nowych technologiach, które umożliwi również stworzenie opartego na DNA zestawu narzędzi molekularnych do charakteryzowania patogenów. W tym celu zespół projektu wykorzysta technologię autonomicznego wykrywania kwasów nukleinowych (Autonomous Detection Nucleic Acids), która nie wymaga zaawansowanego sprzętu, przełomowe rozwiązanie w zakresie naśladowania białek i tworzenia enzymów, a wreszcie robota molekularnego zdolnego do identyfikacji i niszczenia komórek.
Cel
Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens.
First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years.
To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.
Dziedzina nauki
- natural sciencesbiological sciencesgeneticsDNA
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesclinical medicineoncology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Program(-y)
Zaproszenie do składania wniosków
Zobacz inne projekty w ramach tego zaproszeniaSzczegółowe działanie
H2020-FETOPEN-2014-2015-RIA
System finansowania
RIA - Research and Innovation actionKoordynator
1210 Wien
Austria