Opis projektu
Kompleksowa analiza kolistych cząsteczek RNA
Koliste cząsteczki RNA to jednoniciowe, zamknięte cząsteczki kwasu rybonukleinowego, które występują w zróżnicowanych organizmach – od wirusów po ssaki. Cząsteczki te cieszą się obecnie dużym zainteresowaniem naukowców ze względu na ich potencjalny wpływ na choroby związane z podeszłym wiekiem. Zespół finansowanego ze środków działania „Maria Skłodowska-Curie” projektu circRTrain zamierza zbadać proces biogenezy i funkcję kolistych cząsteczek RNA, aby zrozumieć ich znaczenie z punktu widzenia chorób oraz określić, czy mogą być wykorzystywane w roli biomarkerów. W tym celu badacze wykorzystają zróżnicowane technologie oraz modele, by ustalić znaczenie tych cząsteczek z punktu widzenia medycyny. Co więcej, w ramach prac badacze przeszkolą naukowców na początku kariery w zagadnieniach związanych z tą obiecującą i nowatorską dziedziną.
Cel
CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates.
The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines.
Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies).
CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.
Dziedzina nauki
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesclinical medicineoncology
- natural sciencesbiological sciencesgeneticsRNA
- medical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis
Program(-y)
Zaproszenie do składania wniosków
Zobacz inne projekty w ramach tego zaproszeniaSystem finansowania
MSCA-ITN-ETN - European Training NetworksKoordynator
13125 Berlin
Niemcy