Molecular logic lab-on-a-vesicle for intracellular diagnostics

Informacje na temat projektu

LOGIC LAB

Identyfikator umowy o grant: 813920

DOI

10.3030/813920

Projekt został zamknięty

Data podpisania przez KE 17 Sierpnia 2018

Data rozpoczęcia 1 Listopada 2018

Data zakończenia 31 Października 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 538 684,44

Wkład UE

€ 3 538 684,44

Koordynowany przez

LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Other (6)

Awarding of doctoral degrees
Network meeting 4

Network meeting 4 is delivered

Final symposium

Final symposium is held

Network meeting 1

Network meeting 1 is delivered

Network meeting 3

Network meeting 3 is delivered

Network meeting 2

Network meeting 2 is delivered

Documents, reports (9)

Delivery of supramolecular logic gates to living endothelial cells / co-cultures

Based on results from D2.2, a protocol to deliver supramolecular logic gates to living endothelial cells / co-cultures is developed

Animal disease models

Suitable animal disease models are identified

Living 2D cell cultures and co-cultures

Living 2D cell cultures and co-cultures are available

Proof-of-principle for TTA-UC supramolecular sensing

Proof-of-principle for TTA-UC supramolecular sensing is shown

Delivery of supramolecular logic gates to a MemSense or GUV membrane model

A protocol for delivery of supramolecular logic gates to a MemSense or GUV membrane model is established

Metabolomic profile of ED pathology

A metabolomic profile of ED pathology is established

Theoretical models for the excited state levels of the sensors

Theoretical models for the excited state levels of the sensors are established

Stable and well-characterized liposomes

Stable and well-characterized liposomes are prepared to transport the logic gates in buffer and serum

Photochemical and photophysical characteristics

Photochemical and photophysical characteristics are known

Websites, patent fillings, videos etc. (1)

ESR positions are advertised

ESR positions are advertised at national and European-wide portals and the LOGIC LAB website (e.g. Euraxess)

Open Research Data Pilot (1)

Research results are published

Research results are published in peer-reviewed, open access journals and books

Publikacje

Peer reviewed articles (26)

Uptake and anti-inflammatory effects of liposomal astaxanthin on endothelial cells tracked by Raman and fluorescence imaging

Autorzy: Radwan, Basseem Prabhakaran, Amrutha Rocchetti, Stefano Matuszyk, Ewelina Keyes, Tia E. Baranska, Malgorzata
Opublikowane w: Microchim Acta, Numer 190, 2023, ISSN 0026-3672
Wydawca: Springer Verlag
DOI: 10.1007/s00604-023-05888-8

EdU sensing: The Raman way of following endothelial cell proliferation in vitro and ex vivo

Autorzy: Basseem Radwan; Stefano Rocchetti; Ewelina Matuszyk; Magdalena Sternak; Maciej Stodulski; Robert Pawlowski; Jacek Mlynarski; Krzysztof Brzozowski; Stefan Chlopicki; Malgorzata Baranska
Opublikowane w: Biosensors and Bioelectronics, Numer 216, 2022, ISSN 0956-5663
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2022.114624

Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction

Autorzy: Andreeva, Valeriia D. Ehlers, Haley R. C, Aswin Krishna Presselt, Martin J. Van Den Broek, Lenie Bonnet, Sylvestre
Opublikowane w: Communications Chemistry, 2023, ISSN 2399-3669
Wydawca: Springer
DOI: 10.1038/s42004-023-00973-8

Radiative lifetime of a BODIPY dye as calculated by TDDFT and EOM-CCSD methods: solvent and vibronic effects

Autorzy: Rengel Cane E. Sia, Ruben Arturo Arellano-Reyes, Tia E. Keyes , Julien Guthmuller
Opublikowane w: Physical Chemistry Chemical Physics, Numer 23, 2021, Strona(/y) 26324-26335, ISSN 1463-9084
Wydawca: Royal Socienty of Chemistry
DOI: 10.1039/d1cp03775g

Interaction of Miltefosine with Microcavity Supported Lipid Membrane: Biophysical Insights from Electrochemical Impedance Spectroscopy

Autorzy: Nirod Kumar Sarangi, Amrutha Prabhakaran, Tia E. Keyes
Opublikowane w: Electroanalysis, 2020, ISSN 1040-0397
Wydawca: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/elan.202060424

Excited-State Dynamics in Borylated Arylisoquinoline Complexes in Solution and <i>in cellulo</i>

Autorzy: Yang, T. X. Valavalkar, A. Romero-Arenas, A. Dasgupta, A. Then, P. Chettri, A. Eggeling, C. Ros, A. Pischel, U. Dietzek-Ivansic, B.
Opublikowane w: Chemistry-a European Journal, 2023, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202203468

Monitoring excited-state relaxation in a molecular marker in live cells–a case study on astaxanthin

Autorzy: Tingxiang Yang, Avinash Chettri, Basseem Radwan, Ewelina Matuszyk, Malgorzata Baranska, Benjamin Dietzek
Opublikowane w: Chemical Communications, 2021, ISSN 1359-7345
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d1cc01907d

Labeled vs. Label-Free Raman Imaging of Lipids in Endothelial Cells of Various Origins

Autorzy: Basseem Radwan; Adriana Adamczyk; Szymon Tott; Krzysztof Czamara; Katarzyna Kaminska; Ewelina Matuszyk; Malgorzata Baranska
Opublikowane w: Molecules, Numer 25, 2020, Strona(/y) 5752-5760, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25235752

Multiplex Raman imaging of organelles in endothelial cells

Autorzy: Ewelina Matuszyk, Adriana Adamczyk, Basseem Radwan, Anna Pieczara, Piotr Szcześniak, Jacek Mlynarski, Katarzyna Kamińska, Malgorzata Baranska
Opublikowane w: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Numer 255, 2021, Strona(/y) 119658, ISSN 1386-1425
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.saa.2021.119658

Using Biological Photophysics to Map the Excited‐State Topology of Molecular Photosensitizers for Photodynamic Therapy

Autorzy: Avinash Chettri; Tingxiang Yang; Houston D. Cole; Ge Shi; Colin G. Cameron; Sherri A. McFarland; Benjamin Dietzek‐Ivanšić
Opublikowane w: Angewandte Chemie International Edition, Numer 62, 2023, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202301452

A BODIPY‐Based Molecular Rotor in Giant Unilamellar Vesicles: A Case Study by Polarization‐Resolved Time‐Resolved Emission and Transient Absorption Spectroscopy

Autorzy: Keshav Kumar Jha; Amrutha Prabhakaran; Lukas Spantzel; Rengel Cane Sia; Iván Pérez; Ruben Arturo Arellano‐Reyes; Anna Elmanova; Anindita Dasgupta; Christian Eggeling; Michael Börsch; Julien Guthmuller; Martin Presselt; Tia E. Keyes; Benjamin Dietzek‐Ivanšić
Opublikowane w: ChemPhotoChem, Numer 7, 2023, ISSN 2367-0932
Wydawca: John Wiley & Sons, Ltd
DOI: 10.1002/cptc.202300091

Multimodal Investigation into the Interaction of Quinacrine with Microcavity-Supported Lipid Bilayers

Autorzy: Nirod Kumar Sarangi Amrutha Prabhakaran Tia E. Keyes
Opublikowane w: Langmuir, Numer 38 (20), 2022, Strona(/y) 6411–6424, ISSN 0743-7463
Wydawca: American Chemical Society
DOI: 10.1021/acs.langmuir.2c00524

Triplet Formation and Triplet-Triplet Annihilation Upconversion in Iodine Substituted Non-Orthogonal BODIPY-Perylene Dyads

Autorzy: Jha, K. K. Prabhakaran, A. Sia, R. C. Reyes, R. A. A. Sarangi, N. K. Yang, T. X. Kumar, K. Kupfer, S. Guthmuller, J. Keyes, T. E. Dietzek-Ivansic, B.
Opublikowane w: Chemphotochem, 2023, ISSN 2367-0932
Wydawca: John Wiley & Sons
DOI: 10.1002/cptc.202300073

Supramolecular Reorientation During Deposition Onto Metal Surfaces of Quasi-Two-Dimensional Langmuir Monolayers Composed of Bifunctional Amphiphilic, Twisted Perylenes

Autorzy: Hupfer, M. L. Meyer, R. Deckert-Gaudig, T. Ghosh, S. Skabeev, A. Peneva, K. Deckert, V. Dietzek, B. Presselt, M.
Opublikowane w: Langmuir, Numer 37, 2021, ISSN 0743-7463
Wydawca: American Chemical Society
DOI: 10.1021/acs.langmuir.1c01525

In Cellulo Light‐Induced Dynamics in a BODIPY‐Perylene Dyad

Autorzy: Tingxiang Yang; Ruben Arturo Arellano-Reyes; Rhianne C. Curley; Keshav Kumar Jha; Avinash Chettri; Tia E. Keyes; Benjamin Dietzek-Ivanšić
Opublikowane w: Chemistry – A European Journal, Numer 29, 2023, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202300224

Shorter Alkyl Chains Enhance Molecular Diffusion and Electron Transfer Kinetics between Photosensitisers and Catalysts in CO2-Reducing Photocatalytic Liposomes

Autorzy: David M. Klein Dr. Santiago Rodríguez-Jiménez Marlene E. Hoefnagel Dr. Andrea Pannwitz Amrutha Prabhakaran Dr. Maxime A. Siegler Prof. Tia E. Keyes Prof. Erwin Reisner Prof. Albert M. Brouwer Prof. Sylvestre Bonnet
Opublikowane w: Chemistry - A European Journnal, Numer 27, 2021, Strona(/y) 17203-17212, ISSN 1521-3765
Wydawca: Wiley-VCH GmbH, Weinheim
DOI: 10.1002/chem.202102989

Leaflet by Leaflet Synergistic Effects of Antimicrobial Peptides on Bacterial and Mammalian Membrane Models

Autorzy: Arpita Roy; Nirod Kumar Sarangi; Surajit Ghosh; Amrutha Prabhakaran; Tia E. Keyes
Opublikowane w: The Journal of Physical Chemistry Letters, Numer 14, 2023, ISSN 1948-7185
Wydawca: American Chemical Society
DOI: 10.1021/acs.jpclett.3c00119

Toward Raman Subcellular Imaging of Endothelial Dysfunction

Autorzy: Adriana Adamczyk, Ewelina Matuszyk, Basseem Radwan, Stefano Rocchetti, Stefan Chlopicki, Malgorzata Baranska
Opublikowane w: Journal of Medicinal Chemistry, Numer 64/8, 2021, Strona(/y) 4396-4409, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.1c00051

Dichroic Dipole Antenna Membranes from Aligned Linear BOPHY Dyes

Autorzy: Hupfer, M. L. Ghosh, S. Wang, Yingchun Opsomer, Tomas Dehaen, W. Presselt, M.
Opublikowane w: Advanced Materials Interfaces, 2021, ISSN 2196-7350
Wydawca: John Wiley & Sons
DOI: 10.1002/admi.202101490

Astaxanthin as a new Raman probe for biosensing of specific subcellular lipidic structures: can we detect lipids in cells under resonance conditions?

Autorzy: Krzysztof Czamara, Adriana Adamczyk, Marta Stojak, Basseem Radwan, Malgorzata Baranska
Opublikowane w: Cellular and Molecular Life Sciences, 2020, ISSN 1420-682X
Wydawca: Birkhauser Verlag
DOI: 10.1007/s00018-020-03718-1

New Highly Sensitive and Specific Raman Probe for Live Cell Imaging of Mitochondrial Function

Autorzy: Pieczara, Anna Arellano Reyes, Ruben Arturo Keyes, Tia E. Dawiec, Patrycja Baranska, Malgorzata
Opublikowane w: ACS Sensors, Numer 9, 2024, ISSN 2379-3694
Wydawca: American Chemical Society
DOI: 10.1021/acssensors.3c02576

BODIPY‐Perylene Charge Transfer Compounds; Sensitizers for Triplet‐Triplet Annihilation Up‐conversion

Autorzy: Ruben Arturo Arellano‐Reyes; Amrutha Prabhakaran; Rengel Cane E. Sia; Julien Guthmuller; Keshav Kumar Jha; Tingxiang Yang; Benjamin Dietzek‐Ivanšić; Vickie McKee; Tia E. Keyes
Opublikowane w: Chemistry – A European Journal, Numer 29, 2023, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202300239

Vascular inflammation on a chip: A scalable platform for trans-endothelial electrical resistance and immune cell migration

Autorzy: Haley, Ehlers; Arnaud, Nicolas; Frederik, Schavemaker; Jeroen P M, Heijmans; Martin, Bulst; Sebastiaan J, Trietsch; Lenie J, van den Broek
Opublikowane w: Front Immunol, Numer 14, 2023, ISSN 1664-3224
Wydawca: Frontiers Media S.A.
DOI: 10.3389/fimmu.2023.1118624

Triplet–Triplet Annihilation Upconversion by Polymeric Sensitizers

Autorzy: Keshav Kumar Jha Amrutha Prabhakaran Christopher S. Burke Marcus Schulze Ulrich S. Schubert Tia E. Keyes Michael Jäger Benjamin Dietzek Ivanšić
Opublikowane w: Journal of Physical Chemistry C, Numer 126, 2022, Strona(/y) 4057–4066, ISSN 1932-7447
Wydawca: American Chemical Society
DOI: 10.1021/acs.jpcc.1c09897

Bifacial Dye Membranes: Ultrathin and Free-Standing although not Being Covalently Bound

Autorzy: Hupfer, M. L. Dellith, J. Seyring, M. Diegel, M. Dellith, A. Ghosh, S. Rettenmayr, M. Dietzek-Ivansic, B. Presselt, M.
Opublikowane w: Advanced Materials, 2023, ISSN 0935-9648
Wydawca: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202204874

Evaluation of the passive permeability of antidepressants through pore-suspended lipid bilayer

Autorzy: Sarangi, Nirod Kumar Prabhakaran, Amrutha Roantree, Mark Keyes, Tia E.
Opublikowane w: Colloids and Surfaces B: Biointerfaces, 2024, ISSN 0927-7765
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfb.2023.113688

Non-peer reviewed articles (2)

Tracer-based metabolomics for profiling nitric oxide metabolites in a 3D microvessel-on-a-chip model

Autorzy: Pandian, Kanchana Huang, Luojiao Junaid, Abidemi Harms, Amy Van Zonneveld, Anton Jan Hankemeier, Thomas
Opublikowane w: BioRXiv, 2023, ISSN 2692-8205
Wydawca: bioRxiv
DOI: 10.1101/2023.12.03.569402

Triplet-triplet annihilation upconversion for calcium sensing

Autorzy: Andreeva, Valeriia D. Yang, Tingxiang Regeni, Irene Dietzek-Ivanšić, Benjamin Bonnet, Sylvestre A.
Opublikowane w: ChemRxiv, 2023, ISSN 2573-2293
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv-2023-7p1s5