Molecular Bioengineering in health ERA chair

Informacje na temat projektu

MOBILIsE

Identyfikator umowy o grant: 951723

DOI

10.3030/951723

Data podpisania przez KE 19 Czerwca 2020

Data rozpoczęcia 1 Stycznia 2021

Data zakończenia 30 Czerwca 2026

Finansowanie w ramach

• Establishing ‚ERA Chairs’

Koszt całkowity

€ 2 478 155,00

Wkład UE

€ 2 478 155,00

Koordynowany przez

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (4)

Self-assessment of INEB-i3S towards ERA priorities implementation

Report detailing how INEBi3S is positioned in line with the ERA priorities

Curricular plan of the Molecular Bioengineering Module

Report detailing a curricular plan focusing on Molecular Bioengineering for MSc and PhD programmes.

Training and Mentoring Plan

Report detailing main training and mentoring activities required

Dissemination Plan

MOBILIsE dissemination plan with regular updates at M12 M36 M60

Websites, patent fillings, videos etc. (1)

MOBILIsE website

Project website put online

Publikacje

Peer reviewed articles (37)

DETOX: An innovative dendritic nanosystem for the delivery of BoNT/A LC domain to ischemic neurons

Autorzy: Marília Torrado, Clara Sinthon, Duarte Silva, Débora A. Moreira, Natália Magalhães, Frederico Ferreira-da-Silva, Fátima Fonseca, Tomomi Furihata, Marie Piantino, Michiya Matsusaki, Victoria Leiro, Sofia D. Santos, Ana P. Pêgo
Opublikowane w: Biomaterials, Numer 326, 2026, Strona(/y) 123684, ISSN 0142-9612
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2025.123684

Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research

Autorzy: Juliana Viegas, Bruno Sarmento
Opublikowane w: Advanced Drug Delivery Reviews, Numer 208, 2024, Strona(/y) 115295, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2024.115295

Dhvar5- and MSI78-coated titanium are bactericidal against methicillin-resistant Staphylococcus aureus, immunomodulatory and osteogenic

Autorzy: B. Costa, J. Coelho, V. Silva, H. Shahrour, N.A. Costa, A.R. Ribeiro, S.G. Santos, F. Costa, G. Martínez-de-Tejada, C. Monteiro, M.C.L. Martins
Opublikowane w: Acta Biomaterialia, 2024, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2024.11.016

Paving the way for a non-antibiotic and microbiota friendly therapy for Helicobacter pylori: In vitro and in vivo performance of lipid nanoparticles

Autorzy: Catarina Leal Seabra, A. Sofia Pinho, Cláudia Nunes, Irina Amorim, Nicole Pedro, Patrícia Henriques, Cláudia Monteiro, Joana Gomes, Cláudia Machado, Fátima Gartner, Luísa Pereira, Salette Reis, Celso A. Reis, Eliette Touati, Inês C. Gonçalves, Paula Parreira, M. Cristina L. Martins
Opublikowane w: Helicobater, Numer 2024; 29: e13050., 2024, ISSN 1083-4389
Wydawca: Blackwell Publishing Inc.
DOI: 10.1111/hel.13050

Engineered chitosan-derived nanocarrier for efficient siRNA delivery to peripheral and central neurons

Autorzy: Ana P. Spencer, Adriana Vilaça, Miguel Xavier, Rafael Santos, Ariel Ionescu, María Lázaro, Victoria Leiro, Eran Perlson, Sofia C. Guimarães, Ben M. Maoz, Ana P. Pêgo
Opublikowane w: Advanced Healthcare Materials, Numer 2025, Jun; 14(15):e2500107, 2025, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1101/2024.09.05.611434

How can biomaterial-conjugated antimicrobial peptides fight bacteria and be protected from degradation?

Autorzy: Pedro M. Alves, Cristina C. Barrias, Paula Gomes, M. Cristina L. Martins
Opublikowane w: Acta Biomaterialia, Numer Volume 181, June 2024, 2024, Strona(/y) 98-116, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2024.04.043

How Charge, Size and Protein Corona Modulate the Specific Activity of Nanostructured Lipid Carriers (NLC) against Helicobacter pylori

Autorzy: Rute Chitas; Cláudia Nunes; Salette Reis; Paula Parreira; Maria Cristina L. Martins
Opublikowane w: Pharmaceutics, 2022, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122745

Medulloblastoma: biology and immunotherapy

Autorzy: Alessandro Poggi, Francesco Reggiani, Helena S. Azevedo, Lizzia Raffaghello, Rui Cruz Pereira
Opublikowane w: Frontiers in Immunology, Numer 16, 2025, ISSN 1664-3224
Wydawca: Frontiers Media SA
DOI: 10.3389/fimmu.2025.1602930

In vitro models of the interplay between glioblastoma and blood–brain barrier for stratifying drug efficacy

Autorzy: Cecília Ferreira, Bruno Sarmento, Cláudia Martins
Opublikowane w: Advanced Drug Delivery Reviews, Numer 227, 2025, Strona(/y) 115702, ISSN 0169-409X
Wydawca: Elsevier BV
DOI: 10.1016/j.addr.2025.115702

Enhancement of hMSC In Vitro Proliferation by Surface Immobilization of a Heparin-Binding Peptide

Autorzy: Maura Cimino, Paula Parreira, Victoria Leiro, Aureliana Sousa, Raquel M. Gonçalves, Cristina C. Barrias, M. Cristina L. Martins
Opublikowane w: Molecules, 2023, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules28083422

Cholesterol Functionalized Nanoparticles Are Effective against <i>Helicobacter pylori</i>, the Gastric Bug: A Proof‐of‐Concept Study

Autorzy: Ana Sofia Pinho, Renato Pereira, Mariana Pereira, Akhilesh Rai, Lino Ferreira, Maria Cristina Lopes Martins, Paula Parreira
Opublikowane w: Advanced Healthcare Materials, Numer 2025, 2404065, 2025, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202404065

Exploring the Bioactive Potential and Biocompatibility of Extracts from Agro-Industrial Residues for Cosmetic Applications

Autorzy: Sandra M. Gomes, Filipa Campos, M. Cristina L. Martins, Cláudia Monteiro, Lúcia Santos
Opublikowane w: International Journal of Molecular Sciences, Numer 26, 2025, Strona(/y) 9169, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26189169

Abdominal wall hernia repair: from prosthetic meshes to smart materials

Autorzy: Qimanguli Saiding, Yiyao Chen, Juan Wang, Catarina Leite Pereira, Bruno Sarmento, Wenguo Cui, Xinliang Chen
Opublikowane w: Materials Today Bio, 2023, ISSN 2590-0064
Wydawca: Oxford: Elsevier Ltd
DOI: 10.1016/j.mtbio.2023.100691

Nanomedicine approaches for treating glioblastoma

Autorzy: Cláudia Martins; Catarina Pacheco; Paulo Faria; Bruno Sarmento
Opublikowane w: Nanomedicine (Lond.), 2023, ISSN 1743-5889
Wydawca: Future Medicine Ltd.
DOI: 10.2217/nnm-2023-0163

Structuring supramolecular hyaluronan hydrogels via peptide self-assembly for modulating the cell microenvironment

Autorzy: Yichen Yuan, Yejiao Shi, Jayati Banerjee, Amin Sadeghpour, Helena S. Azevedo
Opublikowane w: Materials Today Bio, 2023, ISSN 2590-0064
Wydawca: Oxford: Elsevier Ltd.
DOI: 10.1016/j.mtbio.2023.100598

Targeted nanotherapeutics for the treatment of Helicobacter pylori infection

Autorzy: Rute Chitas, Diana R. Fonseca, Paula Parreira, M. Cristina L. Martins
Opublikowane w: Journal of Biomedical Science, Numer 31, 2024, ISSN 1423-0127
Wydawca: BMC
DOI: 10.1186/s12929-024-01068-9

Organ-on-chip platforms for nanoparticle toxicity and efficacy assessment: Advancing beyond traditional in vitro and in vivo models

Autorzy: Ana Regina Sampaio, Renata Faria Maia, Maria Camilla Ciardulli, Hélder A. Santos, Bruno Sarmento
Opublikowane w: Materials Today Bio, Numer 33, 2025, Strona(/y) 102053, ISSN 2590-0064
Wydawca: Elsevier BV
DOI: 10.1016/j.mtbio.2025.102053

Exploring Low-Power Single-Pulsed Laser-Triggered Two-Photon Photodynamic/Photothermal Combination Therapy Using a Gold Nanostar/Graphene Quantum Dot Nanohybrid

Autorzy: Amir Soleimany; Sepideh Khoee; Sofia Dias; Bruno Sarmento
Opublikowane w: ACS Applied Materials & Interfaces, 2023, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.3c03578

Influence of Immobilization Strategies on the Antibacterial Properties of Antimicrobial Peptide-Chitosan Coatings

Autorzy: Mariana Barbosa; Pedro M. Alves; Fabíola Costa; Cláudia Monteiro; Paula Parreira; Cátia Teixeira; Paula Gomes; Maria Cristina L. Martins
Opublikowane w: Pharmaceuticals, 2023, ISSN 1999-4923
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics15051510

How to manage Helicobacter pylori infection beyond antibiotics: The bioengineering quest

Autorzy: Diana R. Fonseca, Rute Chitas, Paula Parreira, M.Cristina L. Martins
Opublikowane w: Applied Materials Today, 2024, ISSN 2352-9407
Wydawca: Elsevier Ltd.
DOI: 10.1016/j.apmt.2024.102123

Antimicrobial peptide-grafted PLGA-PEG nanoparticles to fight bacterial wound infections

Autorzy: António Miguel Ramôa, Filipa Campos, Luís Moreira, Cátia Teixeira, Victoria Leiro, Paula Gomes, José das Neves, M. Cristina L. Martins, Cláudia Monteiro
Opublikowane w: Biomaterials Science, 2023, ISSN 2047-4849
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d2bm01127a

Nano-in-microparticles approach: Targeted gastric ulcer therapy using trans-resveratrol nanoparticles encapsulated in hyaluronic acid and alginate microparticles

Autorzy: Larissa Spósito, Gessynger Morais-Silva, Diana Fonseca, Matheus Morais Neves, Murilo Vieira Silva, Taís Maria Bauab, Paula Parreira, M. Cristina L. Martins, Andréia Bagliotti Meneguin, Marlus Chorilli
Opublikowane w: International Journal of Biological Macromolecules, Numer 305, 2025, Strona(/y) 141010, ISSN 0141-8130
Wydawca: Elsevier BV
DOI: 10.1016/j.ijbiomac.2025.141010

Hybrid structure combining essential oil derivatives and polydopamine for anti-bacterial coatings

Autorzy: Nathan Jourdainne, Dimitri Mercier, Bruna Costa, Filipa Campos, Claudia Monteiro, Natália Costa, M. Cristina L. Martins, Pascal Thébault
Opublikowane w: Colloids and Surfaces B: Biointerfaces, Numer 252, 2025, Strona(/y) 114679, ISSN 0927-7765
Wydawca: Elsevier BV
DOI: 10.1016/j.colsurfb.2025.114679

Magnetoelectric core-shell nanoparticles for nervous tissue electrostimulation: Performance in In vitro and ex vivo organotypic cultures

Autorzy: Maurizio Gulino, Donghoon Kim, Qiao Tang, Semih Sevim, Elric Zhang, Hao Ye, Xiang-Zhong Chen, Miguel Rafael Gonçalves Morais, Sofia Duque Santos, Salvador Pané, Ana Paula Pêgo
Opublikowane w: Acta Biomaterialia, Numer 209, 2026, Strona(/y) 504-520, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2025.11.038

Bioinspired hybrid DNA/dendrimer-based films with supramolecular chirality

Autorzy: Rita Castro, Pedro L. Granja, João Rodrigues, Ana Paula Pêgo, Helena Tomás
Opublikowane w: Journal of Materials Chemistry B, Numer 13, 2025, Strona(/y) 4671-4680, ISSN 2050-7518
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d4tb02761b

Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

Autorzy: Carlos Redondo-Gómez, Paula Parreira, M. Cristina L. Martins, and Helena S. Azevedo
Opublikowane w: Chemical Society Reviews, Numer "2024, ""Celebrating the scientific accomplishments of RSC Fellows""", 2024, ISSN 1460-4744
Wydawca: Royal Society of Chemistry
DOI: 10.1039/d3cs00921a

Bioengineered hyaluronan hydrogels for the delivery of molecular and cellular therapies

Autorzy: Joana Silva, Helena S. Azevedo
Opublikowane w: Advanced Therapeutics, 2023, ISSN 2366-3987
Wydawca: John Wiley & Sons, Inc.
DOI: 10.1002/adtp.202300182

Antimicrobial peptides-loaded PLGA nanoparticles: Unravelling distinct release profiles and effect against Pseudomonas aeruginosa

Autorzy: Filipa Campos, Ana Baião, Cláudia Monteiro, M. Cristina L. Martins
Opublikowane w: Journal of Drug Delivery Science and Technology, Numer 114, 2026, Strona(/y) 107501, ISSN 1773-2247
Wydawca: Editions de Sante
DOI: 10.1016/j.jddst.2025.107501

Phage Display Identified Peptide with Selectivity for Human Osteoarthritic Chondrocytes

Autorzy: Ivone M. Martins, Raphaël F. Canadas, Hélder Pereira, Joana Azeredo, Rui L. Reis, Joaquim M. Oliveira, Helena S. Azevedo
Opublikowane w: Advanced Therapeutics, 2023, ISSN 2366-3987
Wydawca: John Wiley & Sons, Inc.
DOI: 10.1002/adtp.202300263

Norbornene-chitosan nanoparticles with and without a conjugated VEGF-peptide analog to promote vascularization

Autorzy: Pedro M. Alves, Diana R. Fonseca, Sílvia J. Bidarra, Ana Gomes, Paula Gomes, Cristina C. Barrias, M. Cristina L. Martins
Opublikowane w: Materials Today Chemistry, 2024, ISSN 2468-5194
Wydawca: Science Direct, Elsevier
DOI: 10.1016/j.mtchem.2024.101942

Engineering resveratrol-loaded chitosan nanoparticles for potential use against Helicobacter pylori infection

Autorzy: Larissa Spósito, Diana Fonseca, Suzana Gonçalves Carvalho, Rafael Miguel Sábio, Gabriel Davi Marena, Taís Maria Bauab, Andréia Bagliotti Meneguin, Paula Parreira, M. Cristina L. Martins, Marlus Chorilli
Opublikowane w: European Journal of Pharmaceutics and Biopharmaceutics, Numer 199, 2024, Strona(/y) 114280, ISSN 0939-6411
Wydawca: Elsevier BV
DOI: 10.1016/j.ejpb.2024.114280

Validation of Selective Capture of Fimbriated Uropathogenic <i>Escherichia coli</i> by a Label-free Engineering Detection System Using Mannosylated Surfaces

Autorzy: Leila Mousavifar; Paula Parreira; Alexis Taponard; Vanessa C. D. Graça; M. Cristina L. Martins; René Roy
Opublikowane w: ACS Applied Bio Materials, 2022, ISSN 2576-6422
Wydawca: American Chemical Society
DOI: 10.1021/acsabm.2c00838

Norbornene-chitosan spray-dried microspheres for peptide conjugation using thiol-ene “photoclick” chemistry

Autorzy: Pedro M. Alves; Diana R. Fonseca; Rúben F. Pereira; Berta N. Estevinho; Cátia Teixeira; Paula Gomes; M. Cristina L. Martins
Opublikowane w: Biomecánica, 2022, ISSN 1885-9518
Wydawca: Sociedad Ibérica de Biomecánica y Biomateriales

Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders

Autorzy: Rui Pedro Moura, Eva Daniela Carvalho, Cláudia Martins, Anne des Rieux, Ana Paula Pêgo, Bruno Sarmento
Opublikowane w: Journal of Controlled Release, Numer 358, 2025, Strona(/y) 43-58, ISSN 0168-3659
Wydawca: Elsevier BV
DOI: 10.1016/j.jconrel.2023.04.034

"One-Pot Microfluidics to Engineer Chitosan Nanoparticles Conjugated with Antimicrobial Peptides Using “Photoclick” Chemistry: Validation Using the Gastric Bacterium Helicobacter pylori"""

Autorzy: Diana R Fonseca, Pedro M. Alves, Estrela Neto, Beatriz Custódio, Sofia Guimarães, Duarte Moura, Francesca Annis, Marco Martins, Ana Gomes, Cátia Teixeira, Paula Gomes, Rúben F. Pereira, Paulo Freitas, Paula Parreira, and M. Cristina L. Martins
Opublikowane w: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.3c18772

Chemical engineering of zein with polyethylene glycol and Angiopep-2 to manufacture a brain-targeted docetaxel nanomedicine for glioblastoma treatment

Autorzy: Seem Awad, Marco Araújo, Paulo Faria, Bruno Sarmento, Cláudia Martins
Opublikowane w: Drug Delivery and Translational Research, 2024, ISSN 2190-393X
Wydawca: Springer Pub. Co.,
DOI: 10.1007/s13346-024-01659-x

Dhvar5-chitosan nanogels and their potential to improve antibiotics activity

Autorzy: B. Costa, P.M. Alves, D.R. Fonseca, F. Campos, A.C. Monteiro, H. Shahrour, A. Gomes, F. Costa, P. Gomes, G. Martínez-de-Tejada, C. Monteiro, M.C.L. Martins
Opublikowane w: International Journal of Biological Macromolecules, Numer 277, 2024, Strona(/y) 134059, ISSN 0141-8130
Wydawca: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.134059

Non-peer reviewed articles (1)

Immunoengineering: Voices and impressions on the inaugural MOBILIsE symposium

Autorzy: Jeffrey A. Hubbell, Roy van der Meel, Jennifer H. Elisseeff, Juliane Walz, Carlos-Filipe Pereira, Tiago Ramalho, Rita Acúrcio, Dario Venetz, Susana Monteiro, Pedro Castanheira, Rui C. Pereira, Helena S. Azevedo
Opublikowane w: Cell Biomaterials, Numer 1, 2025, Strona(/y) 100211, ISSN 3050-5623
Wydawca: Elsevier BV
DOI: 10.1016/j.celbio.2025.100211