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Zawartość zarchiwizowana w dniu 2024-05-29

Glycans array fingerprints for the study of synbiotics

Cel

A growing awareness of the relationship between diet and health has led to an increasing demand for food products that are able to enhance health, as well as provide basic nutrition. Synbiotics are functional foods that combine probiotics (living microorganisms) and their substrates - prebiotics. Synbiotics demonstrate synergistic health benefits on the consumer. Synbiotics' mode of action is poorly understood. Even so, it is suggested that synbiotics have antimicrobial, anticarcinogenic, immunomodulatory, antidiarrheal, antiallergenic, and other activities. Therefore, scientific documentation is of major importance for the credibility of the synbiotic products. Glycans play an important part in human nutrition; these include glycoconjugate molecules that are part of food ingredients and secreted glycans from microorganisms in food fermentation.

The issue of glycan analysis technology is repeatedly mentioned as key to the development of safer and better food. As the new head of biochemistry in NutriCognia, I will combine the company technology with the expertise I acquired in the USA to make use of synbiotics' glycan composition as a scientific tool for the characterization and monitoring of synbiotic aspects. Our approach to glycan analysis is based on lectin glycan interactions: glycoanalysis is performed by binding the intact glycoprotein to a lectin array (CarboDeep) and identification by specifically labelled lectin probes. CarboDeep presents a unique approach, that enables efficient, precise, qualitative, and quantitative methods for the study of synbiotics.

We propose to:
(1) optimise CarboDeep technology for the synbiotics field;
(2) develop synbiotic glyco-fingerprinting application, using the synbiotics' glycans biochip; and
(3) develop a biochip with higher specificity for synbiotics' glycans.

The proposed studies will provide a reliable scientific/technological tool for synbiotics analysis and afford a new insight of the synbiotics properties.

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Temat(-y)

Zaproszenie do składania wniosków

FP6-2004-MOBILITY-12
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

IRG - Marie Curie actions-International re-integration grants

Koordynator

NUTRICOGNIA LTD
Wkład UE
Brak danych
Koszt całkowity
Brak danych