Synthetic biology of non-ribosomal peptide synthetases to generate new peptides

Publikacje

Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

Autorzy: Yi-Ming Shi Merle Hirschmann Yan-Ni Shi Shabbir Ahmed Desalegne Abebew, Nicholas J. Tobias, Peter Grün, Jan J. Crames, Laura Pöschel, Wolfgang Kuttenlochner, Christian Richter, Jennifer Herrmann, Rolf Müller, Aunchalee Thanwisai, Sacha J. Pidot, Timothy P. Stinear, Michael Groll, Yonggyun Kim Helge B. Bode
Opublikowane w: Nature Chemistry, 2022, ISSN 1755-4330
Wydawca: Nature Publishing Group
DOI: 10.1038/s41557-022-00923-2

Evolution-inspired engineering of nonribosomal peptide synthetases

Autorzy: Kenan A. J. Bozhueyuek, Leonard Präve, Carsten Kegler, Leonie Schenk, Sebastian Kaiser, Christian Schelhas, Yan-Ni Shi, Wolfgang Kuttenlochner, Max Schreiber, Joshua Kandler, Mohammad Alanjary, T.M. Mohiuddin, Michael Groll, Georg K. A. Hochberg, Helge B. Bode
Opublikowane w: Science, Numer 383 (6689), 2024, Strona(/y) eadg4320, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.adg4320

A Practical Guideline to Engineering Nonribosomal Peptide Synthetases

Autorzy: Nadya Abbood, Leonard Praeve, Kenan Bozhüyük, Helge B. Bode
Opublikowane w: Methods in Molecular Biology (MIMB), Numer 2670, 2023, Strona(/y) 219-234, ISSN 1064-3745
Wydawca: Humana Press, Inc.
DOI: 10.1007/978-1-0716-3214-7

NMR resonance assignments for a docking domain pair with an attached thiolation domain from the PAX peptide-producing NRPS from Xenorhabdus cabanillasii

Autorzy: Jonas Watzel, Sepas Sarawi, Elke Duchardt-Ferner, Helge B. Bode, Jens Wöhnert
Opublikowane w: Biomolecular NMR Assignments, Numer 15/1, 2021, Strona(/y) 229-234, ISSN 1874-2718
Wydawca: Springer Verlag
DOI: 10.1007/s12104-021-10010-1

Type S Non-Ribosomal Peptide Synthetases for the Rapid Generation of Tailormade Peptide Libraries

Autorzy: Nadya Abbood Tien Duy Vo Jonas Watzel Kenan A J Bozhueyuek Helge B Bode
Opublikowane w: Chem Eur J, Numer 09476539, 2022, Strona(/y) e202103963, ISSN 0947-6539
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202103963

Nematode-Associated Bacteria: Production of Antimicrobial Agent as a Presumptive Nominee for Curing Endodontic Infections Caused by Enterococcus faecalis

Autorzy: Hicran Donmez Ozkan, Harun Cimen, Derya Ulug, Sebastian Wenski, Senem Yigit Ozer, Murat Telli, Neriman Aydin, Helge B. Bode, Selcuk Hazir
Opublikowane w: Frontiers in Microbiology, Numer 10, 2019, ISSN 1664-302X
Wydawca: Frontiers Media
DOI: 10.3389/fmicb.2019.02672

Cooperation between a T Domain and a Minimal C‐Terminal Docking Domain to Enable Specific Assembly in a Multiprotein NRPS

Autorzy: Jonas Watzel, Elke Duchardt‐Ferner, Sepas Sarawi, Helge B. Bode, Jens Wöhnert
Opublikowane w: Angewandte Chemie International Edition, 2021, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202103498

Structure and biosynthesis of deoxy-polyamine in Xenorhabdus bovienii

Autorzy: Sebastian L Wenski Natalie Berghaus Nadine Keller Helge B Bode
Opublikowane w: J Ind Microbiol Biotechnol, Numer 13675435, 2021, Strona(/y) kuab006, ISSN 1367-5435
Wydawca: Springer Verlag
DOI: 10.1093/jimb/kuab006

A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments

Autorzy: Eva M. Huber, Lukas Kreling, Antje K. Heinrich, Maximilian Dünnebacke, Alexander Pöthig, Helge B. Bode, Michael Groll
Opublikowane w: Structure, Numer 31 (5), 2023, ISSN 0969-2126
Wydawca: Cell Press
DOI: 10.1016/j.str.2023.03.001

easyPACId, a Simple Method for Induced Production, Isolation, Identification, and Testing of Natural Products from Proteobacteria

Autorzy: Edna Bode, Daniela Assmann, Petra Happel, Elmar Meyer, Karin Münch, Nicole Rössel, Helge B. Bode
Opublikowane w: bio-protocol, Numer 13(13): e4709, 2023, ISSN 2331-8325
Wydawca: Bio-Protocol LLC
DOI: 10.21769/bioprotoc.4709

Genetic toolbox for Photorhabdus and Xenorhabdus: pSEVA based heterologous expression systems and CRISPR/Cpf1 based genome editing for rapid natural product profiling

Autorzy: Alexander Rill, Lei Zhao, Helge B. Bode
Opublikowane w: Microbial Cell Factories, Numer 23 (1), 2024, Strona(/y) 98, ISSN 1475-2859
Wydawca: BioMed Central
DOI: 10.1186/s12934-024-02363-8

Engineering of Specific Single-Module Nonribosomal Peptide Synthetases of the RXP Type for the Production of Defined Peptides

Autorzy: Xiaofeng Cai, Lei Zhao, Helge B. Bode
Opublikowane w: ACS Synthetic Biology, Numer 12 (1), 2023, Strona(/y) 203-212, ISSN 2161-5063
Wydawca: American Chemical Society
DOI: 10.1021/acssynbio.2c00472

Biosynthesis of the multifunctional isopropylstilbene in Photorhabdus laumondii involves cross-talk between specialized and primary metabolism

Autorzy: Siyar Kavakli, Gina L.C.Grammbitter, Helge B.Bode
Opublikowane w: Tetrahedron, 2022, ISSN 1464-5416
Wydawca: Elsevier
DOI: 10.1016/j.tet.2022.133116

Cleavage Off-Loading and Post-assembly-Line Conversions Yield Products with Unusual Termini during Biosynthesis

Autorzy: Yi-Ming Shi Merle Hirschmann Yan-Ni Shi Helge B Bode
Opublikowane w: ACS Chem Biol, Numer 15548929, 2022, Strona(/y) 2221-2228, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.2c00367

Synthetic Zippers as an Enabling Tool for Engineering of Non-Ribosomal Peptide Synthetases

Autorzy: Kenan A. J. Bozhueyuek; Jonas Watzel; Nadya Abbood; Helge B. Bode
Opublikowane w: Angew Chem Int Ed, Numer 1, 2021, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1101/2020.05.06.080655

Genome Mining Enabled by Biosynthetic Characterization Uncovers a Class of Benzoxazolinate-Containing Natural Products in Diverse Bacteria

Autorzy: Yi-Ming Shi Jan J Crames Laura Czech Kenan A J Bozhüyük Yan-Ni Shi Merle Hirschmann Stefanie Lamberth Peter Claus Nicole Paczia Christian Rückert Jörn Kalinowski Gert Bange Helge B Bode
Opublikowane w: Angew Chem Int Ed, Numer 14337851, 2022, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202206106

Activation, Structure, Biosynthesis and Bioactivity of Glidobactin‐like Proteasome Inhibitors from Photorhabdus laumondii

Autorzy: Lei Zhao, Camille Le Chapelain, Alexander O. Brachmann, Marcel Kaiser, Michael Groll, Helge B. Bode
Opublikowane w: ChemBioChem, Numer 22/9, 2021, Strona(/y) 1582-1588, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202100014

Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

Autorzy: Andreas Tietze, Yan‐Ni Shi, Max Kronenwerth, Helge B. Bode
Opublikowane w: ChemBioChem, Numer 21/19, 2020, Strona(/y) 2750-2754, ISSN 1439-4227
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202000176

Integrating genomics and metabolomics for scalable non-ribosomal peptide discovery

Autorzy: Bahar Behsaz, Edna Bode, Alexey Gurevich, Yan-Ni Shi, Florian Grundmann, Deepa Acharya, Andrés Mauricio Caraballo-Rodríguez, Amina Bouslimani, Morgan Panitchpakdi, Annabell Linck, Changhui Guan, Julia Oh, Pieter C. Dorrestein, Helge B. Bode, Pavel A. Pevzner, Hosein Mohimani
Opublikowane w: Nature Communications, Numer 12/1, 2021, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-021-23502-4

Microbial Cationic Peptides as a Natural Defense Mechanism against Insect Antimicrobial Peptides

Autorzy: Tien Duy Vo, Christoph Spahn, Mike Heilemann, Helge B. Bode
Opublikowane w: ACS Chemical Biology, Numer 16/3, 2021, Strona(/y) 447-451, ISSN 1554-8929
Wydawca: American Chemical Society
DOI: 10.1021/acschembio.0c00794

Influence of condensation domains on activity and specificity of adenylation domains

Autorzy: Janik Kranz, Sebastian L. Wenski, Alexander A. Dichter, Helge B. Bode, Kenan A. J. Bozhüyük
Opublikowane w: bioRxiv, 2021, ISSN 2692-8205
Wydawca: Cold Spring Harbor
DOI: 10.1101/2021.08.23.457306

Synthetische Zipper für die Biosynthese neuer Naturstoffderivate

Autorzy: Nadya Abbood Kenan A.J. Bozhüyük Helge B. Bode
Opublikowane w: Biospektrum, Numer 09470867, 2022, Strona(/y) 446-449, ISSN 0947-0867
Wydawca: Spektrum Akademischer Verlag GmbH
DOI: 10.1007/s12268-022-1785-7

The Chemical Structure of Widespread Microbial Aryl Polyene Lipids

Autorzy: Gina L. C. Grammbitter, Yi-Ming Shi, Yan-Ni Shi, Sahithya P. B. Vemulapalli, Christian Richter, Harald Schwalbe, Mohammad Alanjary, Anja Schüffler, Matthias Witt, Christian Griesinger, Helge B. Bode
Opublikowane w: bioRxiv, 2020, ISSN 2692-8205
Wydawca: Cold Spring Harbor
DOI: 10.1101/2020.12.19.423268

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ADAPTER SYSTEM OF ARTIFICIAL NON-RIBOSOMAL PEPTIDE SYNTHETASES AND POLYKETIDE SYNTHASES

Numer wniosku/publikacji: 19 208603
Data: 2019-11-12

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